Analyzing a Genetic Variant of “Unknown Significance: a case study of Science-ing in the agentic era [Part 1]

I’m a genetic testing geek. My future husband and I compared genomes before our first date (23andme). Later I had my full gene workup done by Nebula genomics. When I needed standard embryo genetic testing, I sprung for the full genome variety. And as information comes in about the disease history of family members, I’ve Read More …

I Made Proteins from Custom DNA in My Garage. Almost Nobody Checked. [AKA Glowing Yeast, Custom Plasmids, and a Garage Full of E. coli]

I’ve spent most of my career writing code. But in early 2025, I decided to build something different: a home biohacking lab for education. I wrote about the building process, and today I’m going to share a few key experiments I did with it. All of these experiments and more are available in my lab Read More …

These are the Great Days

Moving up the abstraction stack one Slack post at a time (harness details inside) The “good old days” of hobbyist programming In the early 2010s I was a iOS developer on the side of being a PhD student. The project I cut my teeth on, my collaborators went on to found Stripe. A passion project Read More …

Five Years of Monthly Capsule Wardrobe Lookbooks: enjoying fashion as minimalist who doesn’t like to shop, decide what to wear for the day, or try things on

When I was in college, I came home my freshman year to my mom with a tattered pair of skinny jeans, and she gave me some fantastic, lifelong advice: if I like something, I should get multiple copies of it. To this day that’s what I do. I hate shopping, and for day-to-day it’s difficult Read More …

How I Turned 20,000+ Tweets Into a Vintage Twitter Time Capsule (With an AI Agent)

now available at: twitter.christinecorbettmoran.com Disclaimer: AI assisted writing of this post. I appreciate y’all want bespoke human prose. At the same time, an AI did the heavy lifting project, and I want to share the prompt and the joy so you can be inspired and enabled to easily reproduce. Bespoke human prose would be a Read More …

The Last Generation of Programmers – the first generation of builders

I spent twenty years acquiring a skill set that took a lifetime to build and that no one will ever need to compile again. How I almost missed it I don’t have the stereotypical programmer’s origin story. No disassembling computers at age seven, no BASIC programs typed into the family TV. My path to programming Read More …

Postpartum creative flourishing – an example from the first month with baby 4

A newborn is no vacation, but it can be a sab-baby-cal under the right conditions I’m just past one month of being postpartum with my fourth baby. I  want to share my story of creative flourishing in the postpartum period, because there are a variety of narratives to the contrary and discovering this flourishing has Read More …